RAF Typhoon FGR4s have conducted a mission with France's air force in a coordinated attack targeting an subterranean weapons facility in Syria employed by the Islamic State group (IS), as stated by the UK Ministry of Defence.
The location, located using surveillance, was thought to be storing arms and explosives, the statement said, and was situated in mountainous terrain just to the north of Palmyra in the heart of Syria.
"The RAF jets employed laser-guided Paveway IV weapons to strike a number of entry passages leading to the site... early reports indicate the target was engaged successfully," the MoD said.
There was no indication of any harm to civilians in the strike on Saturday evening and all the aircraft made a safe return, the ministry further stated.
The Typhoon FGR4s were backed up by a Voyager aerial refuelling aircraft.
Daesh - referred to as Daesh - imposed jihadist rule over parts of both Syria and Iraq until 2019.
"This operation demonstrates the UK's leading role, and commitment to operate in unison with allied nations, to eliminate any resurgence of Daesh and their violent and radical beliefs in the area," Britain's Defence Chief the Defence Secretary said.
UK warplanes have performed overwatch operations over Syria to "forestall any attempted comeback" of Islamic State following its routing at the Baghuz confrontation in the year 2019, the ministry said.
"I must thank every member of the UK armed forces who took part in this operation for their skill and their courage," the Defence Secretary said. "They were part of a great many British personnel stationed over the holidays. This mission, to eliminate terrorist threats who threaten our safety, shows how UK forces are prepared to act, continuously, ensuring Britain's security domestically and strong abroad."
Last December, the American forces carried out what it termed a "large-scale strike" against Islamic State objectives in the country, after an ambush resulted in the deaths of two American soldiers and a civilian linguist in the Palmyra area.
The United Nations reports IS still maintains an estimated 5,000 to 7,000 fighters in both countries.